Oncogenic transformation in the absence of Xrcc4 targets peripheral B cells that have undergone editing and switching

Nonhomologous end-joining (NHEJ) repairs DNA double-strand breaks (DSBs) during V(D)J recombination in developing lymphocytes and during immunoglobulin (Ig) heavy chain (IgH) class switch recombination (CSR) in peripheral B lymphocytes. We now show that CD21-cre–mediated deletion of the Xrcc4 NHEJ g...

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Main Authors: Wang, Jing H., Alt, Frederick W., Gostissa, Monica, Datta, Abhishek, Murphy, Michael, Alimzhanov, Marat B., Coakley, Kristen M., Rajewsky, Klaus, Manis, John P., Yan, Catherine T.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2008
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2605230/
https://ncbi.nlm.nih.gov/pubmed/19064702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20082271
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