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Motor neurone targeting of IGF-1 prevents specific force decline in ageing mouse muscle
IGF-1 is a potent growth factor for both motor neurones and skeletal muscle. Muscle IGF-1 is known to provide target-derived trophic effects on motor neurones. Therefore, IGF-1 overexpression in muscle is effective in delaying or preventing deleterious effects of ageing in both tissues. Since age-re...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Blackwell Science Inc
2006
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1464304/ https://ncbi.nlm.nih.gov/pubmed/16293644 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2005.100032 |
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