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Motor neurone targeting of IGF-1 prevents specific force decline in ageing mouse muscle

IGF-1 is a potent growth factor for both motor neurones and skeletal muscle. Muscle IGF-1 is known to provide target-derived trophic effects on motor neurones. Therefore, IGF-1 overexpression in muscle is effective in delaying or preventing deleterious effects of ageing in both tissues. Since age-re...

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Autori principali: Payne, Anthony M, Zheng, Zhenlin, Messi, María Laura, Milligan, Carol E, González, Estela, Delbono, Osvaldo
Natura: Artigo
Lingua:Inglês
Pubblicazione: Blackwell Science Inc 2006
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1464304/
https://ncbi.nlm.nih.gov/pubmed/16293644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2005.100032
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