Mixed backbone antisense oligonucleotides: design, biochemical and biological properties of oligonucleotides containing 2'-5'-ribo- and 3'-5'-deoxyribonucleotide segments.

We have designed and synthesized mixed backbone oligonucleotides (MBOs) containing 2'-5'-ribo- and 3'-5'-deoxyribonucleotide segments. Thermal melting studies of the phosphodiester MBOs (three 2'-5'linkages at each end) with the complementary 3'-5'-DNA and -RNA target strands suggest that 2'-5'-ribo...

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Detalles Bibliográficos

Publicado en:	Nucleic Acids Res
Principais autores:	Kandimalla, E R, Manning, A, Zhao, Q, Shaw, D R, Byrn, R A, Sasisekharan, V, Agrawal, S
Formato:	Artigo
Idioma:	Inglês
Publicado:	Oxford University Press 1997
Assuntos:	Research Article
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC146429/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9016567/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/25.2.370
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