Tryptophan scanning mutagenesis of the HERG K(+) channel: the S4 domain is loosely packed and likely to be lipid exposed

Inherited mutations or drug-induced block of voltage-gated ion channels, including the human ether-à-go-go-related gene (HERG) K(+) channel, are significant causes of malignant arrhythmias and sudden death. The fourth transmembrane domain (S4) of these channels contains multiple positive charges tha...

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Bibliographic Details
Main Authors: Subbiah, Rajesh N, Kondo, Mari, Campbell, Terence J, Vandenberg, Jamie I
Format: Artigo
Language:Inglês
Published: Blackwell Science Inc 2005
Subjects:
Molecular and Genomic Physiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1464230/
https://ncbi.nlm.nih.gov/pubmed/16166152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2005.097386
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