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Tryptophan scanning mutagenesis of the HERG K(+) channel: the S4 domain is loosely packed and likely to be lipid exposed
Inherited mutations or drug-induced block of voltage-gated ion channels, including the human ether-à-go-go-related gene (HERG) K(+) channel, are significant causes of malignant arrhythmias and sudden death. The fourth transmembrane domain (S4) of these channels contains multiple positive charges tha...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Blackwell Science Inc
2005
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1464230/ https://ncbi.nlm.nih.gov/pubmed/16166152 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2005.097386 |
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