Dynamic conformational changes of extracellular S5–P linkers in the hERG channel

The hERG channel has an unusually long ‘S5–P linker’ (residues 571–613) that lines the outer mouth of the pore. Previously, we have shown that residues along this S5–P linker are critical for the fast-inactivation process and K(+) selectivity of the hERG channel. Here we used several approaches to p...

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Hlavní autoři: Jiang, Min, Zhang, Mei, Maslennikov, Innokenty V, Liu, Jie, Wu, Dong-Mei, Korolkova, Yuliya V, Arseniev, Alexander S, Grishin, Eugene V, Tseng, Gea-Ny
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Science Inc 2005
Témata:
Molecular and Genomic Physiology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1464209/
https://ncbi.nlm.nih.gov/pubmed/16150798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2005.093682
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