Dynamic conformational changes of extracellular S5–P linkers in the hERG channel

The hERG channel has an unusually long ‘S5–P linker’ (residues 571–613) that lines the outer mouth of the pore. Previously, we have shown that residues along this S5–P linker are critical for the fast-inactivation process and K(+) selectivity of the hERG channel. Here we used several approaches to p...

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Bibliografiske detaljer
Main Authors: Jiang, Min, Zhang, Mei, Maslennikov, Innokenty V, Liu, Jie, Wu, Dong-Mei, Korolkova, Yuliya V, Arseniev, Alexander S, Grishin, Eugene V, Tseng, Gea-Ny
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Science Inc 2005
Fag:
Molecular and Genomic Physiology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1464209/
https://ncbi.nlm.nih.gov/pubmed/16150798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2005.093682
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