Functional conservation of Pax6 regulatory elements in humans and mice demonstrated with a novel transgenic reporter mouse

BACKGROUND: The Pax6 transcription factor is expressed during development in the eyes and in specific CNS regions, where it is essential for normal cell proliferation and differentiation. Mice lacking one or both copies of the Pax6 gene model closely humans with loss-of-function mutations in the PAX...

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Autori principali: Tyas, David A, Simpson, T Ian, Carr, Catherine B, Kleinjan, Dirk A, van Heyningen, Veronica, Mason, John O, Price, David J
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2006
Soggetti:
Methodology Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1464123/
https://ncbi.nlm.nih.gov/pubmed/16674807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-213X-6-21
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