Lentiviral Expression of Retinal Guanylate Cyclase-1 (RetGC1) Restores Vision in an Avian Model of Childhood Blindness

BACKGROUND: Leber congenital amaurosis (LCA) is a genetically heterogeneous group of retinal diseases that cause congenital blindness in infants and children. Mutations in the GUCY2D gene that encodes retinal guanylate cyclase–1 (retGC1) were the first to be linked to this disease group (LCA type 1...

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Main Authors: Williams, Melissa L, Coleman, Jason E, Haire, Shannon E, Aleman, Tomas S, Cideciyan, Artur V, Sokal, Izabel, Palczewski, Krzysztof, Jacobson, Samuel G, Semple-Rowland, Susan L
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2006
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1463903/
https://ncbi.nlm.nih.gov/pubmed/16700630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pmed.0030201
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