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Free-energy Landscapes of Ion-channel Gating Are Malleable: changes in the number of bound ligands are accompanied by changes in the location of the transition state in acetylcholine-receptor channels

Acetylcholine-receptor channels (AChRs) are allosteric membrane proteins that mediate synaptic transmission by alternatively opening and closing (‘gating’) a cation-selective transmembrane pore. Although ligand binding is not required for the channel to open, the binding of agonists (for example, ac...

Täydet tiedot

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Bibliografiset tiedot
Päätekijä: GROSMAN, CLAUDIO
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2003
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC1463891/
https://ncbi.nlm.nih.gov/pubmed/14674774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi0354334
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