When a helicase is not a helicase: dsDNA tracking by the motor protein EcoR124I

Using a combination of single molecule and bulk solution measurements, we have examined the DNA translocation activity of a helicase, the Type I restriction modification enzyme EcoR124I. We find that EcoR124I can translocate past covalent interstrand crosslinks, inconsistent with an obligatory unwin...

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Bibliografiske detaljer
Main Authors: Stanley, Louise K, Seidel, Ralf, van der Scheer, Carsten, Dekker, Nynke H, Szczelkun, Mark D, Dekker, Cees
Format: Artigo
Sprog:Inglês
Udgivet: 2006
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1462981/
https://ncbi.nlm.nih.gov/pubmed/16642041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601104
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