Role of P1 residues Arg(336) and Arg(562) in the activated-Protein-C-catalysed inactivation of Factor VIIIa

APC (activated Protein C) inactivates human Factor VIIIa following cleavage at residues Arg(336) and Arg(562) within the A1 and A2 subunits respectively. The role of the P1 arginine in APC-catalysed inactivation of Factor VIIIa was examined by employing recombinant Factor VIIIa molecules where resid...

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Main Authors: Varfaj, Fatbardha, Neuberg, Julie, Jenkins, P. Vincent, Wakabayashi, Hironao, Fay, Philip J.
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2006
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1462720/
https://ncbi.nlm.nih.gov/pubmed/16503879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20060117
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