Efficient triple helix formation by oligodeoxyribonucleotides containing alpha- or beta-2-amino-5-(2-deoxy-D-ribofuranosyl) pyridine residues.

Triple helices containing C+xGxC triplets are destabilised at physiological pH due to the requirement for base protonation of 2'-deoxycytidine (dC), which has a pKa of 4.3. The C nucleoside 2-amino-5-(2'-deoxy-beta-D-ribofuranosyl)pyridine (beta-AP) is structurally analogous to dC but is considerabl...

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Publicat a:	Nucleic Acids Res
Autors principals:	Bates, P J, Laughton, C A, Jenkins, T C, Capaldi, D C, Roselt, P D, Reese, C B, Neidle, S
Format:	Artigo
Idioma:	Inglês
Publicat:	Oxford University Press 1996
Matèries:	Research Article
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC146246/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8932369/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/24.21.4176
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