Telomeric and rDNA silencing in Saccharomyces cerevisiae are dependent on a nuclear NAD(+) salvage pathway.

The Sir2 protein is an NAD(+)-dependent protein deacetylase that is required for silencing at the silent mating-type loci, telomeres, and the ribosomal DNA (rDNA). Mutations in the NAD(+) salvage gene NPT1 weaken all three forms of silencing and also cause a reduction in the intracellular NAD(+) lev...

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Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Sandmeier, Joseph J, Celic, Ivana, Boeke, Jef D, Smith, Jeffrey S
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2002
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1462005/
https://ncbi.nlm.nih.gov/pubmed/11901108
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