Directional selection and the site-frequency spectrum.

In this article we explore statistical properties of the maximum-likelihood estimates (MLEs) of the selection and mutation parameters in a Poisson random field population genetics model of directional selection at DNA sites. We derive the asymptotic variances and covariance of the MLEs and explore t...

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Main Authors: Bustamante, C D, Wakeley, J, Sawyer, S, Hartl, D L
Format: Artigo
Sprog:Inglês
Udgivet: 2001
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1461920/
https://ncbi.nlm.nih.gov/pubmed/11779814
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