The short life span of Saccharomyces cerevisiae sgs1 and srs2 mutants is a composite of normal aging processes and mitotic arrest due to defective recombination.

Evidence from many organisms indicates that the conserved RecQ helicases function in the maintenance of genomic stability. Mutation of SGS1 and WRN, which encode RecQ homologues in budding yeast and humans, respectively, results in phenotypes characteristic of premature aging. Mutation of SRS2, anot...

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Detalhes bibliográficos
Main Authors: McVey, M, Kaeberlein, M, Tissenbaum, H A, Guarente, L
Formato: Artigo
Idioma:Inglês
Publicado em: 2001
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1461608/
https://ncbi.nlm.nih.gov/pubmed/11290710
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