Hyper-negative template DNA supercoiling during transcription of the tetracycline-resistance gene in topA mutants is largely constrained in vivo.

The excess linking deficit of plasmid DNA from topoisomerase I-defective bacteria (topA mutants) results mainly from transcription and is commonly ascribed to unbalanced relaxation of transcription-induced twin-supercoiled domains. This defect is aggravated in genes for membrane-binding proteins (su...

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Detalhes bibliográficos

Publicado no:	Nucleic Acids Res
Principais autores:	Albert, A C, Spirito, F, Figueroa-Bossi, N, Bossi, L, Rahmouni, A R
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Oxford University Press 1996
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC146055/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8760899/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/24.15.3093
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