Improving the fidelity of Thermus thermophilus DNA ligase.

The DNA ligase from Thermus thermophilus (Tth DNA ligase) seals single-strand breaks (nicks) in DNA duplex substrates. The specificity and thermostability of this enzyme are exploited in the ligase chain reaction (LCR) and ligase detection reaction (LDR) to distinguish single base mutations associat...

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Bibliografische gegevens

Gepubliceerd in:	Nucleic Acids Res
Hoofdauteurs:	Luo, J, Bergstrom, D E, Barany, F
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	Oxford University Press 1996
Onderwerpen:	Research Article
Online toegang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC146030/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8760896/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/24.15.3071
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