Improving the fidelity of Thermus thermophilus DNA ligase.

The DNA ligase from Thermus thermophilus (Tth DNA ligase) seals single-strand breaks (nicks) in DNA duplex substrates. The specificity and thermostability of this enzyme are exploited in the ligase chain reaction (LCR) and ligase detection reaction (LDR) to distinguish single base mutations associat...

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izdano v:	Nucleic Acids Res
Principais autores:	Luo, J, Bergstrom, D E, Barany, F
Format:	Artigo
Jezik:	Inglês
Izdano:	Oxford University Press 1996
Teme:	Research Article
Online dostop:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC146030/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8760896/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/24.15.3071
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