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Improving the fidelity of Thermus thermophilus DNA ligase.

The DNA ligase from Thermus thermophilus (Tth DNA ligase) seals single-strand breaks (nicks) in DNA duplex substrates. The specificity and thermostability of this enzyme are exploited in the ligase chain reaction (LCR) and ligase detection reaction (LDR) to distinguish single base mutations associat...

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Detalles Bibliográficos
Autores principales: Luo, J, Bergstrom, D E, Barany, F
Formato: Artigo
Lenguaje:Inglês
Publicado: 1996
Materias:
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC146030/
https://ncbi.nlm.nih.gov/pubmed/8760896
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