Bi-directional gene switching with the tetracycline repressor and a novel tetracycline antagonist.

We have screened a panel of tetracycline (tc)-like compounds for their potential use with tc-repressor (tetR) based gene switches. The interaction between tc and tetR appears quite specific, as only tc itself and its close homologues anhydro-tc and doxycycline strongly inhibited DNA binding. However...

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Veröffentlicht in:	Nucleic Acids Res
Hauptverfasser:	Chrast-Balz, J, Hooft van Huijsduijnen, R
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Oxford University Press 1996
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC146027/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8760871/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/24.15.2900
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