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Bi-directional gene switching with the tetracycline repressor and a novel tetracycline antagonist.

We have screened a panel of tetracycline (tc)-like compounds for their potential use with tc-repressor (tetR) based gene switches. The interaction between tc and tetR appears quite specific, as only tc itself and its close homologues anhydro-tc and doxycycline strongly inhibited DNA binding. However...

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Bibliografski detalji
Glavni autori: Chrast-Balz, J, Hooft van Huijsduijnen, R
Format: Artigo
Jezik:Inglês
Izdano: 1996
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC146027/
https://ncbi.nlm.nih.gov/pubmed/8760871
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