Cleavage of oligodeoxyribonucleotides from controlled-pore glass supports and their rapid deprotection by gaseous amines.

A novel method for the deprotection of oligodeoxyribonucleotides has been developed. Gaseous amines such as ammonia or methylamine were employed under pressure to achieve mild and rapid deprotection conditions. For example, oligodeoxyribonucleotides having a (tert-butyl)phenoxyacetyl group for the p...

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Bibliografiske detaljer

Udgivet i:	Nucleic Acids Res
Principais autores:	Boal, J H, Wilk, A, Harindranath, N, Max, E E, Kempe, T, Beaucage, S L
Format:	Artigo
Sprog:	Inglês
Udgivet:	Oxford University Press 1996
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC146024/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8760903/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/24.15.3115
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