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Molecular Basis for the Cu(2+) Binding-Induced Destabilization of β2-Microglobulin Revealed by Molecular Dynamics Simulation
According to experimental data, binding of the Cu(2+) ions destabilizes the native state of β2-microglobulin (β2m). The partial unfolding of the protein was generally considered an early step toward fibril formation in dialysis-related amyloidosis. Recent NMR studies have suggested that the destabil...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Biophysical Society
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1459522/ https://ncbi.nlm.nih.gov/pubmed/16513784 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.105.064444 |
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