The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease

Autosomal-dominant polycystic kidney disease (ADPKD) is a common genetic disorder that frequently leads to renal failure. Mutations in polycystin-1 (PC1) underlie most cases of ADPKD, but the function of PC1 has remained poorly understood. No preventive treatment for this disease is available. Here,...

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Hlavní autoři: Shillingford, Jonathan M., Murcia, Noel S., Larson, Claire H., Low, Seng Hui, Hedgepeth, Ryan, Brown, Nicole, Flask, Chris A., Novick, Andrew C., Goldfarb, David A., Kramer-Zucker, Albrecht, Walz, Gerd, Piontek, Klaus B., Germino, Gregory G., Weimbs, Thomas
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2006
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1459378/
https://ncbi.nlm.nih.gov/pubmed/16567633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0509694103
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