Ciliary exclusion of Polycystin-2 promotes kidney cystogenesis in an autosomal dominant polycystic kidney disease model

The human PKD2 locus encodes Polycystin-2 (PC2), a TRPP channel that localises to several distinct cellular compartments, including the cilium. PKD2 mutations cause Autosomal Dominant Polycystic Kidney Disease (ADPKD) and affect many cellular pathways. Data underlining the importance of ciliary PC2...

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Bibliografske podrobnosti
izdano v:Nat Commun
Main Authors: Walker, Rebecca V., Keynton, Jennifer L., Grimes, Daniel T., Sreekumar, Vrinda, Williams, Debbie J., Esapa, Chris, Wu, Dongsheng, Knight, Martin M., Norris, Dominic P.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2019
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6731238/
https://ncbi.nlm.nih.gov/pubmed/31492868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12067-y
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