Increased sensitivity to thyroid hormone in mice with complete deficiency of thyroid hormone receptor α

Only three of the four thyroid hormone receptor (TR) isoforms, α1, β1, and β2, bind thyroid hormone (TH) and are considered to be true TRs. TRα2 binds to TH response elements on DNA, but its role in vivo is still unknown. We produced mice completely deficient in TRα (TRα(o/o)) that maintain normal s...

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Main Authors: Macchia, Paolo E., Takeuchi, Yoko, Kawai, Tomoko, Cua, Kevin, Gauthier, Karine, Chassande, Olivier, Seo, Hisao, Hayashi, Yoshitaka, Samarut, Jacques, Murata, Yoshiharu, Weiss, Roy E., Refetoff, Samuel
Format: Artigo
Jezik:Inglês
Izdano: The National Academy of Sciences 2001
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC14593/
https://ncbi.nlm.nih.gov/pubmed/11120878
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