Increased sensitivity to thyroid hormone in mice with complete deficiency of thyroid hormone receptor α

Only three of the four thyroid hormone receptor (TR) isoforms, α1, β1, and β2, bind thyroid hormone (TH) and are considered to be true TRs. TRα2 binds to TH response elements on DNA, but its role in vivo is still unknown. We produced mice completely deficient in TRα (TRα(o/o)) that maintain normal s...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Macchia, Paolo E., Takeuchi, Yoko, Kawai, Tomoko, Cua, Kevin, Gauthier, Karine, Chassande, Olivier, Seo, Hisao, Hayashi, Yoshitaka, Samarut, Jacques, Murata, Yoshiharu, Weiss, Roy E., Refetoff, Samuel
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2000
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC14593/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11120878/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.011306998
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