Increased sensitivity to thyroid hormone in mice with complete deficiency of thyroid hormone receptor α
Only three of the four thyroid hormone receptor (TR) isoforms, α1, β1, and β2, bind thyroid hormone (TH) and are considered to be true TRs. TRα2 binds to TH response elements on DNA, but its role in vivo is still unknown. We produced mice completely deficient in TRα (TRα(o/o)) that maintain normal s...
Zapisane w:
| Wydane w: | Proc Natl Acad Sci U S A |
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| Główni autorzy: | , , , , , , , , , , , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
National Academy of Sciences
2000
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC14593/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11120878/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.011306998 |
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