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Cholesterol modification restricts the spread of Shh gradient in the limb bud
Sonic hedgehog (Shh) produced in the zone of polarizing activity is the major determinant of anteroposterior development of the amniote limb. The mature and active Shh protein is cholesterol-modified at its C terminus, and the hydrophobic nature of the modification requires the function of Dispatche...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2006
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1458921/ https://ncbi.nlm.nih.gov/pubmed/16611729 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0600124103 |
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