Absence of the transcription factor CCAAT enhancer binding protein α results in loss of myeloid identity in bcr/abl-induced malignancy

The lineage-determining transcription factor CCAAT enhancer binding protein α (C/EBPα) is required for myeloid differentiation. Decreased function or expression of C/EBPα is often found in human acute myeloid leukemia. However, the precise impact of C/EBPα deficiency on the maturation arrest in leuk...

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Autori principali: Wagner, Katharina, Zhang, Pu, Rosenbauer, Frank, Drescher, Bettina, Kobayashi, Susumu, Radomska, Hanna S., Kutok, Jeffery L., Gilliland, D. Gary, Krauter, Jürgen, Tenen, Daniel G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2006
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1458879/
https://ncbi.nlm.nih.gov/pubmed/16606850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0508143103
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