Discovery of an RNA virus 3′→5′ exoribonuclease that is critically involved in coronavirus RNA synthesis

Replication of the giant RNA genome of severe acute respiratory syndrome (SARS) coronavirus (CoV) and synthesis of as many as eight subgenomic (sg) mRNAs are mediated by a viral replicase-transcriptase of outstanding complexity that includes an essential endoribonuclease activity. Here, we show that...

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Hlavní autoři: Minskaia, Ekaterina, Hertzig, Tobias, Gorbalenya, Alexander E., Campanacci, Valérie, Cambillau, Christian, Canard, Bruno, Ziebuhr, John
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2006
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1458802/
https://ncbi.nlm.nih.gov/pubmed/16549795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0508200103
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