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Discovery of an RNA virus 3′→5′ exoribonuclease that is critically involved in coronavirus RNA synthesis

Replication of the giant RNA genome of severe acute respiratory syndrome (SARS) coronavirus (CoV) and synthesis of as many as eight subgenomic (sg) mRNAs are mediated by a viral replicase-transcriptase of outstanding complexity that includes an essential endoribonuclease activity. Here, we show that...

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Detalhes bibliográficos
Main Authors: Minskaia, Ekaterina, Hertzig, Tobias, Gorbalenya, Alexander E., Campanacci, Valérie, Cambillau, Christian, Canard, Bruno, Ziebuhr, John
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1458802/
https://ncbi.nlm.nih.gov/pubmed/16549795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0508200103
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