Crystal structure and mechanistic determinants of SARS coronavirus nonstructural protein 15 define an endoribonuclease family

The ≈30-kb coronavirus (+)RNA genome is replicated and transcribed by a membrane-bound replicase complex made up of 16 viral nonstructural proteins (nsp) with multiple enzymatic activities. The complex includes an RNA endonuclease, NendoU, that is conserved among nidoviruses but no other RNA virus,...

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Main Authors: Ricagno, Stefano, Egloff, Marie-Pierre, Ulferts, Rachel, Coutard, Bruno, Nurizzo, Didier, Campanacci, Valérie, Cambillau, Christian, Ziebuhr, John, Canard, Bruno
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2006
Ábhair:
Biological Sciences
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2131687/
https://ncbi.nlm.nih.gov/pubmed/16882730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0601708103
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