Ab-induced ectodomain shedding mediates hepatocyte growth factor receptor down-regulation and hampers biological activity

Targeting tyrosine kinase receptors (RTKs) with specific Abs is a promising therapeutic approach for cancer treatment, although the molecular mechanism(s) responsible for the Abs’ biological activity are not completely known. We targeted the transmembrane RTK for hepatocyte growth factor (HGF) with...

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Autori principali: Petrelli, Annalisa, Circosta, Paola, Granziero, Luisa, Mazzone, Massimiliano, Pisacane, Alberto, Fenoglio, Silvia, Comoglio, Paolo M., Giordano, Silvia
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2006
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1458799/
https://ncbi.nlm.nih.gov/pubmed/16547140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0508156103
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