Ab-induced ectodomain shedding mediates hepatocyte growth factor receptor down-regulation and hampers biological activity

Targeting tyrosine kinase receptors (RTKs) with specific Abs is a promising therapeutic approach for cancer treatment, although the molecular mechanism(s) responsible for the Abs’ biological activity are not completely known. We targeted the transmembrane RTK for hepatocyte growth factor (HGF) with...

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Detaylı Bibliyografya
Asıl Yazarlar: Petrelli, Annalisa, Circosta, Paola, Granziero, Luisa, Mazzone, Massimiliano, Pisacane, Alberto, Fenoglio, Silvia, Comoglio, Paolo M., Giordano, Silvia
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2006
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1458799/
https://ncbi.nlm.nih.gov/pubmed/16547140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0508156103
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