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Ab-induced ectodomain shedding mediates hepatocyte growth factor receptor down-regulation and hampers biological activity
Targeting tyrosine kinase receptors (RTKs) with specific Abs is a promising therapeutic approach for cancer treatment, although the molecular mechanism(s) responsible for the Abs’ biological activity are not completely known. We targeted the transmembrane RTK for hepatocyte growth factor (HGF) with...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1458799/ https://ncbi.nlm.nih.gov/pubmed/16547140 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0508156103 |
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