Conditional and specific NF-κB blockade protects pancreatic beta cells from diabetogenic agents

Type 1 diabetes is characterized by the infiltration of inflammatory cells into pancreatic islets of Langerhans, followed by the selective and progressive destruction of insulin-secreting beta cells. Islet-infiltrating leukocytes secrete cytokines such as IL-1β and IFN-γ, which contribute to beta ce...

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Detalhes bibliográficos
Main Authors: Eldor, R., Yeffet, A., Baum, K., Doviner, V., Amar, D., Ben-Neriah, Y., Christofori, G., Peled, A., Carel, J. C., Boitard, C., Klein, T., Serup, P., Eizirik, D. L., Melloul, D.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2006
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1458796/
https://ncbi.nlm.nih.gov/pubmed/16551748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0508166103
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