The viral thymidine kinase gene as a tool for the study of mutagenesis in Trypanosoma brucei.

We have tested the use of thymidine kinase as a negative selection system for Trypanosoma brucei. To this end we have targeted a construct containing a Herpes simplex virus thymidine kinase (TK) gene into the ribosomal DNA array of procyclic T. brucei. This resulted in TK activity 30-50-fold above b...

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Pubblicato in:	Nucleic Acids Res
Autori principali:	Valdés, J, Taylor, M C, Cross, M A, Ligtenberg, M J, Rudenko, G, Borst, P
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Oxford University Press 1996
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC145877/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8657559/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/24.10.1809
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