Substitution of basic amino acids in the basic region stabilizes DNA binding by E12 homodimers.
The E2A gene encodes two alternatively spliced products, E12 and E47. The two proteins differ in their basic helix-loop-helix motifs (bHLH), responsible for DNA binding and dimerization. Although both E12 and E47 can bind to DNA as heterodimers with tissue-specific bHLH proteins, E12 binds to DNA po...
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| Опубликовано в:: | Nucleic Acids Res |
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| Главные авторы: | , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Oxford University Press
1996
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC145871/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8657575/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/24.10.1921 |
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