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Anti-apoptotic signaling by hepatocyte growth factor/Met via the phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase pathways

Hepatocyte growth factor (HGF) is a ligand of the receptor tyrosine kinase encoded by the c-Met protooncogene. HGF/Met signaling has multifunctional effects on various cell types. We sought to determine the role of HGF/Met in apoptosis and identify signal transducers involved in this process. In exp...

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Библиографические подробности
Главные авторы: Xiao, Guang-Hui, Jeffers, Michael, Bellacosa, Alfonso, Mitsuuchi, Yasuhiro, Vande Woude, George F., Testa, Joseph R.
Формат: Artigo
Язык:Inglês
Опубликовано: The National Academy of Sciences 2001
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC14576/
https://ncbi.nlm.nih.gov/pubmed/11134526
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