Base and sugar requirements for RNA cleavage of essential nucleoside residues in internal loop B of the hairpin ribozyme: implications for secondary structure.

The hairpin ribozyme is a small self-cleaving RNA that can be engineered for RNA cleavage in trans and has potential as a therapeutic agent. We have used a chemical synthesis approach to study the requirements of hairpin RNA cleavage for sugar and base moieties in residues of internal loop B, an ess...

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Bibliografische gegevens

Gepubliceerd in:	Nucleic Acids Res
Hoofdauteurs:	Schmidt, S, Beigelman, L, Karpeisky, A, Usman, N, Sorensen, U S, Gait, M J
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	Oxford University Press 1996
Onderwerpen:	Research Article
Online toegang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC145697/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8604296/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/24.4.573
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