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Base and sugar requirements for RNA cleavage of essential nucleoside residues in internal loop B of the hairpin ribozyme: implications for secondary structure.

The hairpin ribozyme is a small self-cleaving RNA that can be engineered for RNA cleavage in trans and has potential as a therapeutic agent. We have used a chemical synthesis approach to study the requirements of hairpin RNA cleavage for sugar and base moieties in residues of internal loop B, an ess...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Schmidt, S, Beigelman, L, Karpeisky, A, Usman, N, Sorensen, U S, Gait, M J
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 1996
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC145697/
https://ncbi.nlm.nih.gov/pubmed/8604296
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