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The Hrd1p ligase complex forms a linchpin between ER-lumenal substrate selection and Cdc48p recruitment
Misfolded proteins of the endoplasmic reticulum (ER) are targeted to the cytoplasm for proteasomal degradation. Key components of this process are ER membrane-bound ubiquitin ligases. These ligases associate with the cytoplasmic AAA-ATPase Cdc48p/p97, which is thought to support the release of malfo...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1456945/ https://ncbi.nlm.nih.gov/pubmed/16619026 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601088 |
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