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Two internal ribosome entry sites mediate the translation of p53 isoforms
The p53 tumour suppressor protein has a crucial role in cell-cycle arrest and apoptosis. Previous reports show that the p53 messenger RNA is translated to produce an amino-terminal-deleted isoform (ΔN-p53) from an internal initiation codon, which acts as a dominant-negative inhibitor of full-length...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1456917/ https://ncbi.nlm.nih.gov/pubmed/16440000 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.embor.7400623 |
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