A Peptide Derived from RNA Recognition Motif 2 of Human La Protein Binds to Hepatitis C Virus Internal Ribosome Entry Site, Prevents Ribosomal Assembly, and Inhibits Internal Initiation of Translation

Human La protein is known to interact with hepatitis C virus (HCV) internal ribosome entry site (IRES) and stimulate translation. Previously, we demonstrated that mutations within HCV SL IV lead to reduced binding to La-RNA recognition motif 2 (RRM2) and drastically affect HCV IRES-mediated translat...

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Bibliographic Details
Main Authors: Pudi, Renuka, Ramamurthy, Sudhamani S., Das, Saumitra
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2005
Subjects:
Genome Replication and Regulation of Viral Gene Expression
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1181605/
https://ncbi.nlm.nih.gov/pubmed/16014945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.15.9842-9853.2005
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