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A Peptide Derived from RNA Recognition Motif 2 of Human La Protein Binds to Hepatitis C Virus Internal Ribosome Entry Site, Prevents Ribosomal Assembly, and Inhibits Internal Initiation of Translation
Human La protein is known to interact with hepatitis C virus (HCV) internal ribosome entry site (IRES) and stimulate translation. Previously, we demonstrated that mutations within HCV SL IV lead to reduced binding to La-RNA recognition motif 2 (RRM2) and drastically affect HCV IRES-mediated translat...
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| Main Authors: | , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Microbiology
2005
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| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1181605/ https://ncbi.nlm.nih.gov/pubmed/16014945 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.15.9842-9853.2005 |
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