The Hepatitis C Virus RNA 3′-Untranslated Region Strongly Enhances Translation Directed by the Internal Ribosome Entry Site

The positive-strand RNA genome of the hepatitis C virus (HCV) is flanked by 5′- and 3′-untranslated regions (UTRs). Translation of the viral RNA is directed by the internal ribosome entry site (IRES) in the 5′-UTR, and subsequent viral RNA replication requires sequences in the 3′-UTR and in the 5′-U...

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Bibliographic Details
Main Authors: Song, Yutong, Friebe, Peter, Tzima, Eleni, Jünemann, Christiane, Bartenschlager, Ralf, Niepmann, Michael
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2006
Subjects:
Genome Replication and Regulation of Viral Gene Expression
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1642618/
https://ncbi.nlm.nih.gov/pubmed/16971433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00675-06
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