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Two internal ribosome entry sites mediate the translation of p53 isoforms

The p53 tumour suppressor protein has a crucial role in cell-cycle arrest and apoptosis. Previous reports show that the p53 messenger RNA is translated to produce an amino-terminal-deleted isoform (ΔN-p53) from an internal initiation codon, which acts as a dominant-negative inhibitor of full-length...

詳細記述

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書誌詳細
主要な著者: Ray, Partho Sarothi, Grover, Richa, Das, Saumitra
フォーマット: Artigo
言語:Inglês
出版事項: 2006
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC1456917/
https://ncbi.nlm.nih.gov/pubmed/16440000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.embor.7400623
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