Interactions Among DNA Ligase I, the Flap Endonuclease and Proliferating Cell Nuclear Antigen in the Expansion and Contraction of CAG Repeat Tracts in Yeast

Among replication mutations that destabilize CAG repeat tracts, mutations of RAD27, encoding the flap endonuclease, and CDC9, encoding DNA ligase I, increase the incidence of repeat tract expansions to the greatest extent. Both enzymes bind to proliferating cell nuclear antigen (PCNA). To understand...

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Autores principales: Refsland, Eric W., Livingston, Dennis M.
Formato: Artigo
Lenguaje:Inglês
Publicado: Copyright © 2005 by the Genetics Society of America 2005
Materias:
Investigations
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1456850/
https://ncbi.nlm.nih.gov/pubmed/16079237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.105.043448
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