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Interactions Among DNA Ligase I, the Flap Endonuclease and Proliferating Cell Nuclear Antigen in the Expansion and Contraction of CAG Repeat Tracts in Yeast

Among replication mutations that destabilize CAG repeat tracts, mutations of RAD27, encoding the flap endonuclease, and CDC9, encoding DNA ligase I, increase the incidence of repeat tract expansions to the greatest extent. Both enzymes bind to proliferating cell nuclear antigen (PCNA). To understand...

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Библиографические подробности
Главные авторы: Refsland, Eric W., Livingston, Dennis M.
Формат: Artigo
Язык:Inglês
Опубликовано: Copyright © 2005 by the Genetics Society of America 2005
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1456850/
https://ncbi.nlm.nih.gov/pubmed/16079237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.105.043448
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