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A new immunosuppressant, FTY720, induces bcl-2-associated apoptotic cell death in human lymphocytes.

FTY720 is a unique immunosuppressive drug produced by modification of a metabolite from Isaria sinclairii. In vitro treatment of human mononuclear cells with FTY720 resulted in a dose-dependent reduction of cell viability. These treated cells demonstrated characteristic DNA ladder formation on agaro...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Suzuki, S, Li, X K, Enosawa, S, Shinomiya, T
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1996
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1456592/
https://ncbi.nlm.nih.gov/pubmed/9014815
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